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Ophthotech OPH2003

This trial has ended

Research Title: A Phase 2B Randomized, Double-Masked, Controlled Trial to Assess the Safety and Efficacy of Intravitreous Administration of Zimura® (Anti-C5 Aptamer) in Subjects With Geographic Atrophy Secondary to Dry Age-Related Macular Degeneration

Sponsor: Ophthotech Corporation

Principal Investigator: Atul Sharma, M.D.

Description: The objectives of this study are to evaluate the safety and efficacy of intravitreous administration of Zimura® when administered in subjects with geographic atrophy (GA) secondary to dry age-related macular degeneration (AMD).

Approximately 300 subjects will be randomized in a 1:1:1 ratio to the following dose groups:

  • Zimura® Dose 1
  • Zimura® Dose 2
  • Sham

Subjects will receive monthly intravitreal injections of Zimura® or Sham for 18 months. An interim analysis will be conducted, following which, the study may be expanded to include more subjects.

Start Date: January 2016

Recruitment: Completed

Project Personnel: Leslie Marcus, CCRC; Caitlin Harrison, CCRC, COA; Stephanie Campbell, CRC, COA

Location(s): Marietta, 833 Campbell Hill Street, Suite 300, Marietta, GA 30060

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